23  PNI

Note for Pathologists: Perineural Invasion (PNI) detection rates across all interpreters (Pathologists with/without AI, and the AI model itself).

PNI
Total
Negative Positive
Interpreter


    P1 768 (95%) 42 (5.2%) 810 (100%)
    P1AI 770 (95%) 40 (4.9%) 810 (100%)
    P2 788 (97%) 22 (2.7%) 810 (100%)
    P2AI 780 (96%) 30 (3.7%) 810 (100%)
    P3 782 (97%) 28 (3.5%) 810 (100%)
    P3AI 774 (96%) 36 (4.4%) 810 (100%)
    P4 780 (96%) 30 (3.7%) 810 (100%)
    P4AI 768 (95%) 42 (5.2%) 810 (100%)
    AI 684 (84%) 126 (16%) 810 (100%)
Total 6,894 (95%) 396 (5.4%) 7,290 (100%)

23.0.1 PNI agreement

PNI agreement:: Pathologists no AI

Note for Pathologists: Inter-rater agreement for PNI detection among the 4 pathologists, WITHOUT AI assistance.


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              810   
   Raters                                  4   
   Agreement %                      94.93827   
   Kappa                           0.6195544   
   z                                43.19143   
   p-value        < .0000001   
 ───────────────────────────────────────────── 

PNI agreement:: Pathologists with AI

Note for Pathologists: Inter-rater agreement for PNI detection among the 4 pathologists, WITH AI assistance.


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              810   
   Raters                                  4   
   Agreement %                      94.32099   
   Kappa                           0.6554316   
   z                                45.69256   
   p-value        < .0000001   
 ─────────────────────────────────────────────