6 Agreement Decision

7 Distribution and Agreement of Diagnosis on Core Level

7.1 Malignant, Benign, Suspicious Consult, Suspicious IHC

When the diagnoses are given as “Malignant, Benign, Suspicious Require Consult, Suspicious Require IHC” without the AI the agreement among patologist is 73% (Kappa = 0.68, p<0.001). The agreement increases to 91% with AI (Kappa = 0.88, p<0.001).

Malignant, Benign, Suspicious Consult, Suspicious IHC, agreement among 4 pathologist, noAI

Malignant, Benign, Suspicious Consult, Suspicious IHC, agreement among 4 pathologist, withAI

7.2 Benign, Suspicious, Malignant

Transition of Agreement States from Without AI to With AI
Without AI	With AI	Cores	% of Total	% of Row	% of Column	Transition Type
All Agreed	All Agreed	597	72.1	97.9	78.9	No Change
No Agreement	All Agreed	36	4.3	60.0	4.8	Improvement
Majority Agreed	All Agreed	124	15.0	78.5	16.4	Improvement
All Agreed	Majority Agreed	10	1.2	1.6	20.4	Worsening
Majority Agreed	Majority Agreed	25	3.0	15.8	51.0	No Change
No Agreement	Majority Agreed	14	1.7	23.3	28.6	Improvement
Majority Agreed	No Agreement	9	1.1	5.7	40.9	Worsening
All Agreed	No Agreement	3	0.4	0.5	13.6	Worsening
No Agreement	No Agreement	10	1.2	16.7	45.5	No Change

Agreement Changes in Relation to AI Diagnosis

Note for Pathologists: This table details how agreement levels changed (e.g., from ‘No Agreement’ to ‘All Agreed’) stratified by the AI’s diagnosis.

Agreement (no AI)	Agreement (with AI)	AI Diagnosis	Report (Clinical)	Reference Diagnosis	count
Agreement Changes by AI Diagnosis and Reference Diagnosis
All Agreed	All Agreed	Absent	Absent	Absent	423
All Agreed	All Agreed	Present	Absent	ASAP	1
All Agreed	All Agreed	Present	Absent	Absent	2
All Agreed	All Agreed	Present	Present	Present	166
All Agreed	Majority Agreed	Absent	Absent	Absent	6
All Agreed	Majority Agreed	Absent	Present	Present	1
All Agreed	Majority Agreed	Present	Absent	Absent	1
All Agreed	Majority Agreed	Present	Present	Present	2
All Agreed	No Agreement	Present	Absent	Absent	1
All Agreed	No Agreement	Present	Absent	Present	2
Majority Agreed	All Agreed	Absent	Absent	Absent	107
Majority Agreed	All Agreed	Present	Absent	Absent	3
Majority Agreed	All Agreed	Present	Absent	Present	3
Majority Agreed	All Agreed	Present	Present	Present	11
Majority Agreed	Majority Agreed	Absent	Absent	Absent	13
Majority Agreed	Majority Agreed	Present	Absent	Absent	6
Majority Agreed	Majority Agreed	Present	Absent	Present	2
Majority Agreed	Majority Agreed	Present	Present	Present	4
Majority Agreed	No Agreement	Absent	Absent	Absent	4
Majority Agreed	No Agreement	Present	Absent	Absent	3
Majority Agreed	No Agreement	Present	Absent	Present	1
Majority Agreed	No Agreement	Present	Present	Present	1
No Agreement	All Agreed	Absent	Absent	Absent	28
No Agreement	All Agreed	Present	Present	Present	8
No Agreement	Majority Agreed	Absent	Absent	Absent	9
No Agreement	Majority Agreed	Present	Absent	Absent	1
No Agreement	Majority Agreed	Present	Absent	Present	1
No Agreement	Majority Agreed	Present	Present	Present	3
No Agreement	No Agreement	Absent	Absent	Absent	5
No Agreement	No Agreement	Present	Absent	Absent	1
No Agreement	No Agreement	Present	Present	Present	4

Note for Pathologists: This table shows the number of cases that improved or worsened in agreement when the AI’s diagnosis matched the majority opinion of the pathologists.

AI_agrees_with_majority_noAI	Improvement	No Change	Worsening
Improvement when AI Agrees with Majority
FALSE	174	627	22

Compare with Reference Diagnosis

Note for Pathologists: This table assesses whether the diagnostic changes influenced by AI led to a correct or incorrect diagnosis compared to the ground truth.

diagnosis_change	count	percentage
Diagnostic Accuracy Changes
Remained incorrect	823	100.0

Individual Pathologist Analysis

Note for Pathologists: This table summarizes the rate at which each individual pathologist changed their diagnosis after reviewing the AI results.

P1_change_rate	P2_change_rate	P3_change_rate	P4_change_rate	avg_changes_per_case
Rate of Diagnosis Change by Pathologist
15.7	5.6	8.3	11.5	0.4

Note for Pathologists: This table identifies cases where the pathologist’s diagnosis changed to match the AI’s diagnosis after review, indicating potential AI influence.

P1_influence_rate	P2_influence_rate	P3_influence_rate	P4_influence_rate
AI Influence Rate by Pathologist
0.0	0.0	0.0	0.0

Analyze Specific Cases Where AI Influenced Agreement

Note for Pathologists: This table lists specific cases where the AI significantly influenced the agreement among pathologists (e.g., creating consensus where there was none).

Slide_Label	agreement_status_noAI_g1	agreement_status_withAI_g1	P1_noAI_Diagnosis_g1	P2_noAI_Diagnosis_g1	P3_noAI_Diagnosis_g1	P4_noAI_Diagnosis_g1	P1_withAI_Diagnosis_g1	P2_withAI_Diagnosis_g1	P3_withAI_Diagnosis_g1	P4_withAI_Diagnosis_g1	Dx_Paige	Dx_Report	Dx_Research
Cases with Significant Agreement Changes (First 10)
c13_s15.svs	All Agreed	No Agreement	Benign	Benign	Benign	Benign	Suspicious	Malignant	Benign	Benign	Present	Absent	Present
c19_s11.svs	No Agreement	All Agreed	Benign	Benign	Suspicious	Suspicious	Benign	Benign	Benign	Benign	Absent	Absent	Absent
c2_s2.svs	No Agreement	All Agreed	Benign	Benign	Suspicious	Suspicious	Benign	Benign	Benign	Benign	Absent	Absent	Absent
c2_s7.svs	No Agreement	All Agreed	Malignant	Benign	Benign	Suspicious	Benign	Benign	Benign	Benign	Absent	Absent	Absent
c20_s1.svs	No Agreement	All Agreed	Suspicious	Benign	Benign	Suspicious	Benign	Benign	Benign	Benign	Absent	Absent	Absent
c22_s10.svs	No Agreement	All Agreed	Suspicious	Benign	Suspicious	Benign	Benign	Benign	Benign	Benign	Absent	Absent	Absent
c22_s8.svs	No Agreement	All Agreed	Suspicious	Benign	Malignant	Suspicious	Benign	Benign	Benign	Benign	Absent	Absent	Absent
c23_s1.svs	No Agreement	All Agreed	Suspicious	Benign	Suspicious	Benign	Benign	Benign	Benign	Benign	Absent	Absent	Absent
c23_s5.svs	No Agreement	All Agreed	Suspicious	Benign	Benign	Suspicious	Benign	Benign	Benign	Benign	Absent	Absent	Absent
c26_s12.svs	No Agreement	All Agreed	Suspicious	Benign	Benign	Suspicious	Benign	Benign	Benign	Benign	Absent	Absent	Absent

Case Study Dashboard

For cases where pathologists’ agreement pattern changed significantly, you could create a dashboard-style visualization:

[[1]]
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      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c13_s15.svs</td>
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[[2]]
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#vtxwbtmdnh div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
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</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c19_s11.svs</td>
    </tr>
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      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
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  </tbody>
  
</table>
</div>

[[3]]
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</div>

[[4]]
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</div>

[[5]]
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</div>

[[6]]
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}

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}

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#kceeiytlog .katex-display {
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#kceeiytlog div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
  height: 0px !important;
}
</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c22_s10.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
    </tr>
    <tr class="gt_col_headings">
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
    </tr>
  </thead>
  <tbody class="gt_table_body">
    <tr><td headers="Pathologist" class="gt_row gt_left">P1</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P3</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">AI</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

[[7]]
<div id="gzeijzejnr" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
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}

#gzeijzejnr p {
  margin: 0;
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}

#gzeijzejnr .gt_table {
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  border-left-color: #D3D3D3;
}

#gzeijzejnr .gt_caption {
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}

#gzeijzejnr .gt_title {
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}

#gzeijzejnr .gt_heading {
  background-color: #FFFFFF;
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  border-left-color: #D3D3D3;
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}

#gzeijzejnr .gt_bottom_border {
  border-bottom-style: solid;
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}

#gzeijzejnr .gt_col_headings {
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}

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  vertical-align: middle;
}

#gzeijzejnr .gt_from_md > :first-child {
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#gzeijzejnr .gt_from_md > :last-child {
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  margin: 10px;
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  border-top-color: #D3D3D3;
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  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
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  vertical-align: middle;
  overflow-x: hidden;
}

#gzeijzejnr .gt_stub {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
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  text-transform: inherit;
  border-right-style: solid;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  padding-left: 5px;
  padding-right: 5px;
}

#gzeijzejnr .gt_stub_row_group {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  text-transform: inherit;
  border-right-style: solid;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  padding-left: 5px;
  padding-right: 5px;
  vertical-align: top;
}

#gzeijzejnr .gt_row_group_first td {
  border-top-width: 2px;
}

#gzeijzejnr .gt_row_group_first th {
  border-top-width: 2px;
}

#gzeijzejnr .gt_summary_row {
  color: #333333;
  background-color: #FFFFFF;
  text-transform: inherit;
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
}

#gzeijzejnr .gt_first_summary_row {
  border-top-style: solid;
  border-top-color: #D3D3D3;
}

#gzeijzejnr .gt_first_summary_row.thick {
  border-top-width: 2px;
}

#gzeijzejnr .gt_last_summary_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#gzeijzejnr .gt_grand_summary_row {
  color: #333333;
  background-color: #FFFFFF;
  text-transform: inherit;
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
}

#gzeijzejnr .gt_first_grand_summary_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-top-style: double;
  border-top-width: 6px;
  border-top-color: #D3D3D3;
}

#gzeijzejnr .gt_last_grand_summary_row_top {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-style: double;
  border-bottom-width: 6px;
  border-bottom-color: #D3D3D3;
}

#gzeijzejnr .gt_striped {
  background-color: rgba(128, 128, 128, 0.05);
}

#gzeijzejnr .gt_table_body {
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#gzeijzejnr .gt_footnotes {
  color: #333333;
  background-color: #FFFFFF;
  border-bottom-style: none;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#gzeijzejnr .gt_footnote {
  margin: 0px;
  font-size: 90%;
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  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#gzeijzejnr .gt_sourcenotes {
  color: #333333;
  background-color: #FFFFFF;
  border-bottom-style: none;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#gzeijzejnr .gt_sourcenote {
  font-size: 90%;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#gzeijzejnr .gt_left {
  text-align: left;
}

#gzeijzejnr .gt_center {
  text-align: center;
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#gzeijzejnr .gt_right {
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  font-variant-numeric: tabular-nums;
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#gzeijzejnr .gt_font_normal {
  font-weight: normal;
}

#gzeijzejnr .gt_font_bold {
  font-weight: bold;
}

#gzeijzejnr .gt_font_italic {
  font-style: italic;
}

#gzeijzejnr .gt_super {
  font-size: 65%;
}

#gzeijzejnr .gt_footnote_marks {
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  vertical-align: 0.4em;
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#gzeijzejnr .gt_asterisk {
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#gzeijzejnr .gt_indent_1 {
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}

#gzeijzejnr .gt_indent_2 {
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#gzeijzejnr .gt_indent_3 {
  text-indent: 15px;
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#gzeijzejnr .gt_indent_4 {
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#gzeijzejnr .gt_indent_5 {
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#gzeijzejnr .katex-display {
  display: inline-flex !important;
  margin-bottom: 0.75em !important;
}

#gzeijzejnr div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
  height: 0px !important;
}
</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c22_s8.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
    </tr>
    <tr class="gt_col_headings">
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
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  <tbody class="gt_table_body">
    <tr><td headers="Pathologist" class="gt_row gt_left">P1</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P3</td>
<td headers="Without_AI" class="gt_row gt_left">2</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">AI</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

[[8]]
<div id="vrltitntpm" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
  <style>#vrltitntpm table {
  font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
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  -moz-osx-font-smoothing: grayscale;
}

#vrltitntpm thead, #vrltitntpm tbody, #vrltitntpm tfoot, #vrltitntpm tr, #vrltitntpm td, #vrltitntpm th {
  border-style: none;
}

#vrltitntpm p {
  margin: 0;
  padding: 0;
}

#vrltitntpm .gt_table {
  display: table;
  border-collapse: collapse;
  line-height: normal;
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  margin-right: auto;
  color: #333333;
  font-size: 16px;
  font-weight: normal;
  font-style: normal;
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  width: auto;
  border-top-style: solid;
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  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #A8A8A8;
  border-left-style: none;
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  border-left-color: #D3D3D3;
}

#vrltitntpm .gt_caption {
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#vrltitntpm .gt_title {
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  padding-bottom: 4px;
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}

#vrltitntpm .gt_heading {
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  border-right-color: #D3D3D3;
}

#vrltitntpm .gt_bottom_border {
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#vrltitntpm .gt_col_headings {
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#vrltitntpm .gt_column_spanner_outer:first-child {
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#vrltitntpm div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
  height: 0px !important;
}
</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c23_s1.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
    </tr>
    <tr class="gt_col_headings">
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
    </tr>
  </thead>
  <tbody class="gt_table_body">
    <tr><td headers="Pathologist" class="gt_row gt_left">P1</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P3</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">AI</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

[[9]]
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</div>

[[10]]
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</style>
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  <thead>
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</table>
</div>

[[11]]
<div id="yeuezskstc" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
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#yeuezskstc .gt_from_md > :first-child {
  margin-top: 0;
}

#yeuezskstc .gt_from_md > :last-child {
  margin-bottom: 0;
}

#yeuezskstc .gt_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  margin: 10px;
  border-top-style: solid;
  border-top-width: 1px;
  border-top-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
  vertical-align: middle;
  overflow-x: hidden;
}

#yeuezskstc .gt_stub {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  text-transform: inherit;
  border-right-style: solid;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  padding-left: 5px;
  padding-right: 5px;
}

#yeuezskstc .gt_stub_row_group {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  text-transform: inherit;
  border-right-style: solid;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  padding-left: 5px;
  padding-right: 5px;
  vertical-align: top;
}

#yeuezskstc .gt_row_group_first td {
  border-top-width: 2px;
}

#yeuezskstc .gt_row_group_first th {
  border-top-width: 2px;
}

#yeuezskstc .gt_summary_row {
  color: #333333;
  background-color: #FFFFFF;
  text-transform: inherit;
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
}

#yeuezskstc .gt_first_summary_row {
  border-top-style: solid;
  border-top-color: #D3D3D3;
}

#yeuezskstc .gt_first_summary_row.thick {
  border-top-width: 2px;
}

#yeuezskstc .gt_last_summary_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#yeuezskstc .gt_grand_summary_row {
  color: #333333;
  background-color: #FFFFFF;
  text-transform: inherit;
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
}

#yeuezskstc .gt_first_grand_summary_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-top-style: double;
  border-top-width: 6px;
  border-top-color: #D3D3D3;
}

#yeuezskstc .gt_last_grand_summary_row_top {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-style: double;
  border-bottom-width: 6px;
  border-bottom-color: #D3D3D3;
}

#yeuezskstc .gt_striped {
  background-color: rgba(128, 128, 128, 0.05);
}

#yeuezskstc .gt_table_body {
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#yeuezskstc .gt_footnotes {
  color: #333333;
  background-color: #FFFFFF;
  border-bottom-style: none;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#yeuezskstc .gt_footnote {
  margin: 0px;
  font-size: 90%;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#yeuezskstc .gt_sourcenotes {
  color: #333333;
  background-color: #FFFFFF;
  border-bottom-style: none;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#yeuezskstc .gt_sourcenote {
  font-size: 90%;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#yeuezskstc .gt_left {
  text-align: left;
}

#yeuezskstc .gt_center {
  text-align: center;
}

#yeuezskstc .gt_right {
  text-align: right;
  font-variant-numeric: tabular-nums;
}

#yeuezskstc .gt_font_normal {
  font-weight: normal;
}

#yeuezskstc .gt_font_bold {
  font-weight: bold;
}

#yeuezskstc .gt_font_italic {
  font-style: italic;
}

#yeuezskstc .gt_super {
  font-size: 65%;
}

#yeuezskstc .gt_footnote_marks {
  font-size: 75%;
  vertical-align: 0.4em;
  position: initial;
}

#yeuezskstc .gt_asterisk {
  font-size: 100%;
  vertical-align: 0;
}

#yeuezskstc .gt_indent_1 {
  text-indent: 5px;
}

#yeuezskstc .gt_indent_2 {
  text-indent: 10px;
}

#yeuezskstc .gt_indent_3 {
  text-indent: 15px;
}

#yeuezskstc .gt_indent_4 {
  text-indent: 20px;
}

#yeuezskstc .gt_indent_5 {
  text-indent: 25px;
}

#yeuezskstc .katex-display {
  display: inline-flex !important;
  margin-bottom: 0.75em !important;
}

#yeuezskstc div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
  height: 0px !important;
}
</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c29_s7.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
    </tr>
    <tr class="gt_col_headings">
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
    </tr>
  </thead>
  <tbody class="gt_table_body">
    <tr><td headers="Pathologist" class="gt_row gt_left">P1</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P3</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">AI</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

[[12]]
<div id="hwlrlupbar" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
  <style>#hwlrlupbar table {
  font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

#hwlrlupbar thead, #hwlrlupbar tbody, #hwlrlupbar tfoot, #hwlrlupbar tr, #hwlrlupbar td, #hwlrlupbar th {
  border-style: none;
}

#hwlrlupbar p {
  margin: 0;
  padding: 0;
}

#hwlrlupbar .gt_table {
  display: table;
  border-collapse: collapse;
  line-height: normal;
  margin-left: auto;
  margin-right: auto;
  color: #333333;
  font-size: 16px;
  font-weight: normal;
  font-style: normal;
  background-color: #FFFFFF;
  width: auto;
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #A8A8A8;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #A8A8A8;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
}

#hwlrlupbar .gt_caption {
  padding-top: 4px;
  padding-bottom: 4px;
}

#hwlrlupbar .gt_title {
  color: #333333;
  font-size: 125%;
  font-weight: initial;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-color: #FFFFFF;
  border-bottom-width: 0;
}

#hwlrlupbar .gt_subtitle {
  color: #333333;
  font-size: 85%;
  font-weight: initial;
  padding-top: 3px;
  padding-bottom: 5px;
  padding-left: 5px;
  padding-right: 5px;
  border-top-color: #FFFFFF;
  border-top-width: 0;
}

#hwlrlupbar .gt_heading {
  background-color: #FFFFFF;
  text-align: center;
  border-bottom-color: #FFFFFF;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
}

#hwlrlupbar .gt_bottom_border {
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#hwlrlupbar .gt_col_headings {
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
}

#hwlrlupbar .gt_col_heading {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: normal;
  text-transform: inherit;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
  vertical-align: bottom;
  padding-top: 5px;
  padding-bottom: 6px;
  padding-left: 5px;
  padding-right: 5px;
  overflow-x: hidden;
}

#hwlrlupbar .gt_column_spanner_outer {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: normal;
  text-transform: inherit;
  padding-top: 0;
  padding-bottom: 0;
  padding-left: 4px;
  padding-right: 4px;
}

#hwlrlupbar .gt_column_spanner_outer:first-child {
  padding-left: 0;
}

#hwlrlupbar .gt_column_spanner_outer:last-child {
  padding-right: 0;
}

#hwlrlupbar .gt_column_spanner {
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  vertical-align: bottom;
  padding-top: 5px;
  padding-bottom: 5px;
  overflow-x: hidden;
  display: inline-block;
  width: 100%;
}

#hwlrlupbar .gt_spanner_row {
  border-bottom-style: hidden;
}

#hwlrlupbar .gt_group_heading {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  text-transform: inherit;
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
  vertical-align: middle;
  text-align: left;
}

#hwlrlupbar .gt_empty_group_heading {
  padding: 0.5px;
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  vertical-align: middle;
}

#hwlrlupbar .gt_from_md > :first-child {
  margin-top: 0;
}

#hwlrlupbar .gt_from_md > :last-child {
  margin-bottom: 0;
}

#hwlrlupbar .gt_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  margin: 10px;
  border-top-style: solid;
  border-top-width: 1px;
  border-top-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
  vertical-align: middle;
  overflow-x: hidden;
}

#hwlrlupbar .gt_stub {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  text-transform: inherit;
  border-right-style: solid;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  padding-left: 5px;
  padding-right: 5px;
}

#hwlrlupbar .gt_stub_row_group {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  text-transform: inherit;
  border-right-style: solid;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  padding-left: 5px;
  padding-right: 5px;
  vertical-align: top;
}

#hwlrlupbar .gt_row_group_first td {
  border-top-width: 2px;
}

#hwlrlupbar .gt_row_group_first th {
  border-top-width: 2px;
}

#hwlrlupbar .gt_summary_row {
  color: #333333;
  background-color: #FFFFFF;
  text-transform: inherit;
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
}

#hwlrlupbar .gt_first_summary_row {
  border-top-style: solid;
  border-top-color: #D3D3D3;
}

#hwlrlupbar .gt_first_summary_row.thick {
  border-top-width: 2px;
}

#hwlrlupbar .gt_last_summary_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#hwlrlupbar .gt_grand_summary_row {
  color: #333333;
  background-color: #FFFFFF;
  text-transform: inherit;
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
}

#hwlrlupbar .gt_first_grand_summary_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-top-style: double;
  border-top-width: 6px;
  border-top-color: #D3D3D3;
}

#hwlrlupbar .gt_last_grand_summary_row_top {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-style: double;
  border-bottom-width: 6px;
  border-bottom-color: #D3D3D3;
}

#hwlrlupbar .gt_striped {
  background-color: rgba(128, 128, 128, 0.05);
}

#hwlrlupbar .gt_table_body {
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#hwlrlupbar .gt_footnotes {
  color: #333333;
  background-color: #FFFFFF;
  border-bottom-style: none;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#hwlrlupbar .gt_footnote {
  margin: 0px;
  font-size: 90%;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#hwlrlupbar .gt_sourcenotes {
  color: #333333;
  background-color: #FFFFFF;
  border-bottom-style: none;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#hwlrlupbar .gt_sourcenote {
  font-size: 90%;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#hwlrlupbar .gt_left {
  text-align: left;
}

#hwlrlupbar .gt_center {
  text-align: center;
}

#hwlrlupbar .gt_right {
  text-align: right;
  font-variant-numeric: tabular-nums;
}

#hwlrlupbar .gt_font_normal {
  font-weight: normal;
}

#hwlrlupbar .gt_font_bold {
  font-weight: bold;
}

#hwlrlupbar .gt_font_italic {
  font-style: italic;
}

#hwlrlupbar .gt_super {
  font-size: 65%;
}

#hwlrlupbar .gt_footnote_marks {
  font-size: 75%;
  vertical-align: 0.4em;
  position: initial;
}

#hwlrlupbar .gt_asterisk {
  font-size: 100%;
  vertical-align: 0;
}

#hwlrlupbar .gt_indent_1 {
  text-indent: 5px;
}

#hwlrlupbar .gt_indent_2 {
  text-indent: 10px;
}

#hwlrlupbar .gt_indent_3 {
  text-indent: 15px;
}

#hwlrlupbar .gt_indent_4 {
  text-indent: 20px;
}

#hwlrlupbar .gt_indent_5 {
  text-indent: 25px;
}

#hwlrlupbar .katex-display {
  display: inline-flex !important;
  margin-bottom: 0.75em !important;
}

#hwlrlupbar div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
  height: 0px !important;
}
</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c29_s14.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
    </tr>
    <tr class="gt_col_headings">
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
    </tr>
  </thead>
  <tbody class="gt_table_body">
    <tr><td headers="Pathologist" class="gt_row gt_left">P1</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P3</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
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<td headers="Without_AI" class="gt_row gt_left">Absent</td>
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</div>

[[13]]
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</style>
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  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c29_s18.svs</td>
    </tr>
    <tr class="gt_heading">
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</div>

[[14]]
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#paabkiehqz div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
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</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c30_s5.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
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    <tr class="gt_col_headings">
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      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
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<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
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<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
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<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">AI</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

[[15]]
<div id="kozzpncakn" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
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#kozzpncakn thead, #kozzpncakn tbody, #kozzpncakn tfoot, #kozzpncakn tr, #kozzpncakn td, #kozzpncakn th {
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}

#kozzpncakn p {
  margin: 0;
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#kozzpncakn .gt_table {
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#kozzpncakn .gt_caption {
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  border-left-width: 2px;
  border-left-color: #D3D3D3;
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  border-right-width: 2px;
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  color: #333333;
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  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
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  border-right-width: 2px;
  border-right-color: #D3D3D3;
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#kozzpncakn div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
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}
</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c30_s3.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
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      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
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<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
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<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
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<td headers="With_AI" class="gt_row gt_left">1</td></tr>
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<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
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<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

[[16]]
<div id="xmroqfvemw" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
  <style>#xmroqfvemw table {
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</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c30_s11.svs</td>
    </tr>
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      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
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      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
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  </tbody>
  
</table>
</div>

[[17]]
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  padding-right: 5px;
}

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  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
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  border-top-color: #D3D3D3;
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  border-top-color: #D3D3D3;
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  border-left-color: #D3D3D3;
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#llzschaulk .katex-display {
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#llzschaulk div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
  height: 0px !important;
}
</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c30_s15.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
    </tr>
    <tr class="gt_col_headings">
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
    </tr>
  </thead>
  <tbody class="gt_table_body">
    <tr><td headers="Pathologist" class="gt_row gt_left">P1</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P3</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">AI</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

[[18]]
<div id="xpimrezhco" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
  <style>#xpimrezhco table {
  font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

#xpimrezhco thead, #xpimrezhco tbody, #xpimrezhco tfoot, #xpimrezhco tr, #xpimrezhco td, #xpimrezhco th {
  border-style: none;
}

#xpimrezhco p {
  margin: 0;
  padding: 0;
}

#xpimrezhco .gt_table {
  display: table;
  border-collapse: collapse;
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  margin-right: auto;
  color: #333333;
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  font-weight: normal;
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  width: auto;
  border-top-style: solid;
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  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
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  border-bottom-width: 2px;
  border-bottom-color: #A8A8A8;
  border-left-style: none;
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  border-left-color: #D3D3D3;
}

#xpimrezhco .gt_caption {
  padding-top: 4px;
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}

#xpimrezhco .gt_title {
  color: #333333;
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#xpimrezhco .gt_subtitle {
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}

#xpimrezhco .gt_heading {
  background-color: #FFFFFF;
  text-align: center;
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  border-left-color: #D3D3D3;
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  border-right-width: 1px;
  border-right-color: #D3D3D3;
}

#xpimrezhco .gt_bottom_border {
  border-bottom-style: solid;
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}

#xpimrezhco .gt_col_headings {
  border-top-style: solid;
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  border-left-color: #D3D3D3;
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  border-right-width: 1px;
  border-right-color: #D3D3D3;
}

#xpimrezhco .gt_col_heading {
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  padding-bottom: 6px;
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  padding-right: 5px;
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}

#xpimrezhco .gt_column_spanner_outer {
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#xpimrezhco .gt_column_spanner_outer:first-child {
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#xpimrezhco .gt_column_spanner {
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}

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}

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  padding-left: 5px;
  padding-right: 5px;
  vertical-align: top;
}

#xpimrezhco .gt_row_group_first td {
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#xpimrezhco .gt_row_group_first th {
  border-top-width: 2px;
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  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
}

#xpimrezhco .gt_first_summary_row {
  border-top-style: solid;
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  padding-left: 5px;
  padding-right: 5px;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#xpimrezhco .gt_grand_summary_row {
  color: #333333;
  background-color: #FFFFFF;
  text-transform: inherit;
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
}

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  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-top-style: double;
  border-top-width: 6px;
  border-top-color: #D3D3D3;
}

#xpimrezhco .gt_last_grand_summary_row_top {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-style: double;
  border-bottom-width: 6px;
  border-bottom-color: #D3D3D3;
}

#xpimrezhco .gt_striped {
  background-color: rgba(128, 128, 128, 0.05);
}

#xpimrezhco .gt_table_body {
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#xpimrezhco .gt_footnotes {
  color: #333333;
  background-color: #FFFFFF;
  border-bottom-style: none;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#xpimrezhco .gt_footnote {
  margin: 0px;
  font-size: 90%;
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}

#xpimrezhco .gt_sourcenotes {
  color: #333333;
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  border-bottom-style: none;
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  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#xpimrezhco .gt_sourcenote {
  font-size: 90%;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#xpimrezhco .gt_left {
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}

#xpimrezhco .gt_center {
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#xpimrezhco .gt_right {
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#xpimrezhco .gt_font_normal {
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#xpimrezhco .gt_font_bold {
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}

#xpimrezhco .gt_font_italic {
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}

#xpimrezhco .gt_super {
  font-size: 65%;
}

#xpimrezhco .gt_footnote_marks {
  font-size: 75%;
  vertical-align: 0.4em;
  position: initial;
}

#xpimrezhco .gt_asterisk {
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  vertical-align: 0;
}

#xpimrezhco .gt_indent_1 {
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#xpimrezhco .gt_indent_2 {
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#xpimrezhco .gt_indent_3 {
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#xpimrezhco .gt_indent_4 {
  text-indent: 20px;
}

#xpimrezhco .gt_indent_5 {
  text-indent: 25px;
}

#xpimrezhco .katex-display {
  display: inline-flex !important;
  margin-bottom: 0.75em !important;
}

#xpimrezhco div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
  height: 0px !important;
}
</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c30_s9.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
    </tr>
    <tr class="gt_col_headings">
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
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  <tbody class="gt_table_body">
    <tr><td headers="Pathologist" class="gt_row gt_left">P1</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P3</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">AI</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

[[19]]
<div id="hgpgupezsd" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
  <style>#hgpgupezsd table {
  font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

#hgpgupezsd thead, #hgpgupezsd tbody, #hgpgupezsd tfoot, #hgpgupezsd tr, #hgpgupezsd td, #hgpgupezsd th {
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}

#hgpgupezsd p {
  margin: 0;
  padding: 0;
}

#hgpgupezsd .gt_table {
  display: table;
  border-collapse: collapse;
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  margin-right: auto;
  color: #333333;
  font-size: 16px;
  font-weight: normal;
  font-style: normal;
  background-color: #FFFFFF;
  width: auto;
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #A8A8A8;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #A8A8A8;
  border-left-style: none;
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  border-left-color: #D3D3D3;
}

#hgpgupezsd .gt_caption {
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#hgpgupezsd .gt_title {
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}

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</style>
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      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c32_s8.svs</td>
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</div>

[[20]]
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</div>

[[21]]
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[[22]]
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</div>

[[23]]
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</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
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</table>
</div>

[[24]]
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</style>
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  <thead>
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</div>

[[25]]
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</div>

[[26]]
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[[27]]
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  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c50_s4.svs</td>
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    <tr class="gt_heading">
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</table>
</div>

[[28]]
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</div>

[[29]]
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<td headers="With_AI" class="gt_row gt_left">Present</td></tr>
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<td headers="With_AI" class="gt_row gt_left">Present</td></tr>
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</table>
</div>

[[30]]
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  <thead>
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</div>

[[31]]
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</div>

[[32]]
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[[33]]
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</style>
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  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c58_s7.svs</td>
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</table>
</div>

[[34]]
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</div>

[[35]]
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</div>

[[36]]
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</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c59_s15.svs</td>
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</div>

[[37]]
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}

#ctxjaqkltn .gt_footnote {
  margin: 0px;
  font-size: 90%;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#ctxjaqkltn .gt_sourcenotes {
  color: #333333;
  background-color: #FFFFFF;
  border-bottom-style: none;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#ctxjaqkltn .gt_sourcenote {
  font-size: 90%;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#ctxjaqkltn .gt_left {
  text-align: left;
}

#ctxjaqkltn .gt_center {
  text-align: center;
}

#ctxjaqkltn .gt_right {
  text-align: right;
  font-variant-numeric: tabular-nums;
}

#ctxjaqkltn .gt_font_normal {
  font-weight: normal;
}

#ctxjaqkltn .gt_font_bold {
  font-weight: bold;
}

#ctxjaqkltn .gt_font_italic {
  font-style: italic;
}

#ctxjaqkltn .gt_super {
  font-size: 65%;
}

#ctxjaqkltn .gt_footnote_marks {
  font-size: 75%;
  vertical-align: 0.4em;
  position: initial;
}

#ctxjaqkltn .gt_asterisk {
  font-size: 100%;
  vertical-align: 0;
}

#ctxjaqkltn .gt_indent_1 {
  text-indent: 5px;
}

#ctxjaqkltn .gt_indent_2 {
  text-indent: 10px;
}

#ctxjaqkltn .gt_indent_3 {
  text-indent: 15px;
}

#ctxjaqkltn .gt_indent_4 {
  text-indent: 20px;
}

#ctxjaqkltn .gt_indent_5 {
  text-indent: 25px;
}

#ctxjaqkltn .katex-display {
  display: inline-flex !important;
  margin-bottom: 0.75em !important;
}

#ctxjaqkltn div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
  height: 0px !important;
}
</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c6_s10.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
    </tr>
    <tr class="gt_col_headings">
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
    </tr>
  </thead>
  <tbody class="gt_table_body">
    <tr><td headers="Pathologist" class="gt_row gt_left">P1</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P3</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">2</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">AI</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

[[38]]
<div id="qxehmfigru" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
  <style>#qxehmfigru table {
  font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

#qxehmfigru thead, #qxehmfigru tbody, #qxehmfigru tfoot, #qxehmfigru tr, #qxehmfigru td, #qxehmfigru th {
  border-style: none;
}

#qxehmfigru p {
  margin: 0;
  padding: 0;
}

#qxehmfigru .gt_table {
  display: table;
  border-collapse: collapse;
  line-height: normal;
  margin-left: auto;
  margin-right: auto;
  color: #333333;
  font-size: 16px;
  font-weight: normal;
  font-style: normal;
  background-color: #FFFFFF;
  width: auto;
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #A8A8A8;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #A8A8A8;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
}

#qxehmfigru .gt_caption {
  padding-top: 4px;
  padding-bottom: 4px;
}

#qxehmfigru .gt_title {
  color: #333333;
  font-size: 125%;
  font-weight: initial;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-color: #FFFFFF;
  border-bottom-width: 0;
}

#qxehmfigru .gt_subtitle {
  color: #333333;
  font-size: 85%;
  font-weight: initial;
  padding-top: 3px;
  padding-bottom: 5px;
  padding-left: 5px;
  padding-right: 5px;
  border-top-color: #FFFFFF;
  border-top-width: 0;
}

#qxehmfigru .gt_heading {
  background-color: #FFFFFF;
  text-align: center;
  border-bottom-color: #FFFFFF;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
}

#qxehmfigru .gt_bottom_border {
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#qxehmfigru .gt_col_headings {
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
}

#qxehmfigru .gt_col_heading {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: normal;
  text-transform: inherit;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
  vertical-align: bottom;
  padding-top: 5px;
  padding-bottom: 6px;
  padding-left: 5px;
  padding-right: 5px;
  overflow-x: hidden;
}

#qxehmfigru .gt_column_spanner_outer {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: normal;
  text-transform: inherit;
  padding-top: 0;
  padding-bottom: 0;
  padding-left: 4px;
  padding-right: 4px;
}

#qxehmfigru .gt_column_spanner_outer:first-child {
  padding-left: 0;
}

#qxehmfigru .gt_column_spanner_outer:last-child {
  padding-right: 0;
}

#qxehmfigru .gt_column_spanner {
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  vertical-align: bottom;
  padding-top: 5px;
  padding-bottom: 5px;
  overflow-x: hidden;
  display: inline-block;
  width: 100%;
}

#qxehmfigru .gt_spanner_row {
  border-bottom-style: hidden;
}

#qxehmfigru .gt_group_heading {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  text-transform: inherit;
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
  vertical-align: middle;
  text-align: left;
}

#qxehmfigru .gt_empty_group_heading {
  padding: 0.5px;
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  vertical-align: middle;
}

#qxehmfigru .gt_from_md > :first-child {
  margin-top: 0;
}

#qxehmfigru .gt_from_md > :last-child {
  margin-bottom: 0;
}

#qxehmfigru .gt_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  margin: 10px;
  border-top-style: solid;
  border-top-width: 1px;
  border-top-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
  vertical-align: middle;
  overflow-x: hidden;
}

#qxehmfigru .gt_stub {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  text-transform: inherit;
  border-right-style: solid;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  padding-left: 5px;
  padding-right: 5px;
}

#qxehmfigru .gt_stub_row_group {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: initial;
  text-transform: inherit;
  border-right-style: solid;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  padding-left: 5px;
  padding-right: 5px;
  vertical-align: top;
}

#qxehmfigru .gt_row_group_first td {
  border-top-width: 2px;
}

#qxehmfigru .gt_row_group_first th {
  border-top-width: 2px;
}

#qxehmfigru .gt_summary_row {
  color: #333333;
  background-color: #FFFFFF;
  text-transform: inherit;
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
}

#qxehmfigru .gt_first_summary_row {
  border-top-style: solid;
  border-top-color: #D3D3D3;
}

#qxehmfigru .gt_first_summary_row.thick {
  border-top-width: 2px;
}

#qxehmfigru .gt_last_summary_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#qxehmfigru .gt_grand_summary_row {
  color: #333333;
  background-color: #FFFFFF;
  text-transform: inherit;
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
}

#qxehmfigru .gt_first_grand_summary_row {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-top-style: double;
  border-top-width: 6px;
  border-top-color: #D3D3D3;
}

#qxehmfigru .gt_last_grand_summary_row_top {
  padding-top: 8px;
  padding-bottom: 8px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-style: double;
  border-bottom-width: 6px;
  border-bottom-color: #D3D3D3;
}

#qxehmfigru .gt_striped {
  background-color: rgba(128, 128, 128, 0.05);
}

#qxehmfigru .gt_table_body {
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#qxehmfigru .gt_footnotes {
  color: #333333;
  background-color: #FFFFFF;
  border-bottom-style: none;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#qxehmfigru .gt_footnote {
  margin: 0px;
  font-size: 90%;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#qxehmfigru .gt_sourcenotes {
  color: #333333;
  background-color: #FFFFFF;
  border-bottom-style: none;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
}

#qxehmfigru .gt_sourcenote {
  font-size: 90%;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
}

#qxehmfigru .gt_left {
  text-align: left;
}

#qxehmfigru .gt_center {
  text-align: center;
}

#qxehmfigru .gt_right {
  text-align: right;
  font-variant-numeric: tabular-nums;
}

#qxehmfigru .gt_font_normal {
  font-weight: normal;
}

#qxehmfigru .gt_font_bold {
  font-weight: bold;
}

#qxehmfigru .gt_font_italic {
  font-style: italic;
}

#qxehmfigru .gt_super {
  font-size: 65%;
}

#qxehmfigru .gt_footnote_marks {
  font-size: 75%;
  vertical-align: 0.4em;
  position: initial;
}

#qxehmfigru .gt_asterisk {
  font-size: 100%;
  vertical-align: 0;
}

#qxehmfigru .gt_indent_1 {
  text-indent: 5px;
}

#qxehmfigru .gt_indent_2 {
  text-indent: 10px;
}

#qxehmfigru .gt_indent_3 {
  text-indent: 15px;
}

#qxehmfigru .gt_indent_4 {
  text-indent: 20px;
}

#qxehmfigru .gt_indent_5 {
  text-indent: 25px;
}

#qxehmfigru .katex-display {
  display: inline-flex !important;
  margin-bottom: 0.75em !important;
}

#qxehmfigru div.Reactable > div.rt-table > div.rt-thead > div.rt-tr.rt-tr-group-header > div.rt-th-group:after {
  height: 0px !important;
}
</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c6_s8.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
    </tr>
    <tr class="gt_col_headings">
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
    </tr>
  </thead>
  <tbody class="gt_table_body">
    <tr><td headers="Pathologist" class="gt_row gt_left">P1</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P3</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">2</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">AI</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

[[39]]
<div id="pgxrupdiju" style="padding-left:0px;padding-right:0px;padding-top:10px;padding-bottom:10px;overflow-x:auto;overflow-y:auto;width:auto;height:auto;">
  <style>#pgxrupdiju table {
  font-family: system-ui, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji';
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

#pgxrupdiju thead, #pgxrupdiju tbody, #pgxrupdiju tfoot, #pgxrupdiju tr, #pgxrupdiju td, #pgxrupdiju th {
  border-style: none;
}

#pgxrupdiju p {
  margin: 0;
  padding: 0;
}

#pgxrupdiju .gt_table {
  display: table;
  border-collapse: collapse;
  line-height: normal;
  margin-left: auto;
  margin-right: auto;
  color: #333333;
  font-size: 16px;
  font-weight: normal;
  font-style: normal;
  background-color: #FFFFFF;
  width: auto;
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #A8A8A8;
  border-right-style: none;
  border-right-width: 2px;
  border-right-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #A8A8A8;
  border-left-style: none;
  border-left-width: 2px;
  border-left-color: #D3D3D3;
}

#pgxrupdiju .gt_caption {
  padding-top: 4px;
  padding-bottom: 4px;
}

#pgxrupdiju .gt_title {
  color: #333333;
  font-size: 125%;
  font-weight: initial;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 5px;
  padding-right: 5px;
  border-bottom-color: #FFFFFF;
  border-bottom-width: 0;
}

#pgxrupdiju .gt_subtitle {
  color: #333333;
  font-size: 85%;
  font-weight: initial;
  padding-top: 3px;
  padding-bottom: 5px;
  padding-left: 5px;
  padding-right: 5px;
  border-top-color: #FFFFFF;
  border-top-width: 0;
}

#pgxrupdiju .gt_heading {
  background-color: #FFFFFF;
  text-align: center;
  border-bottom-color: #FFFFFF;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
}

#pgxrupdiju .gt_bottom_border {
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
}

#pgxrupdiju .gt_col_headings {
  border-top-style: solid;
  border-top-width: 2px;
  border-top-color: #D3D3D3;
  border-bottom-style: solid;
  border-bottom-width: 2px;
  border-bottom-color: #D3D3D3;
  border-left-style: none;
  border-left-width: 1px;
  border-left-color: #D3D3D3;
  border-right-style: none;
  border-right-width: 1px;
  border-right-color: #D3D3D3;
}

#pgxrupdiju .gt_col_heading {
  color: #333333;
  background-color: #FFFFFF;
  font-size: 100%;
  font-weight: normal;
  text-transform: inherit;
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</style>
  <table class="gt_table" data-quarto-disable-processing="false" data-quarto-bootstrap="false">
  <thead>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_title gt_font_normal" style>Case Study: c6_s7.svs</td>
    </tr>
    <tr class="gt_heading">
      <td colspan="3" class="gt_heading gt_subtitle gt_font_normal gt_bottom_border" style>Transition: No Agreement → All Agreed</td>
    </tr>
    <tr class="gt_col_headings">
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Pathologist">Pathologist</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="Without_AI">Without_AI</th>
      <th class="gt_col_heading gt_columns_bottom_border gt_left" rowspan="1" colspan="1" scope="col" id="With_AI">With_AI</th>
    </tr>
  </thead>
  <tbody class="gt_table_body">
    <tr><td headers="Pathologist" class="gt_row gt_left">P1</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P2</td>
<td headers="Without_AI" class="gt_row gt_left">3</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P3</td>
<td headers="Without_AI" class="gt_row gt_left">1</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">P4</td>
<td headers="Without_AI" class="gt_row gt_left">2</td>
<td headers="With_AI" class="gt_row gt_left">1</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">AI</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
    <tr><td headers="Pathologist" class="gt_row gt_left">Reference</td>
<td headers="Without_AI" class="gt_row gt_left">Absent</td>
<td headers="With_AI" class="gt_row gt_left">Absent</td></tr>
  </tbody>
  
</table>
</div>

Analyze the Effect of AI Diagnosis Types

Note for Pathologists: This table analyzes how different AI diagnosis types (Benign vs Malignant) influence the pattern of pathologist agreement.

Dx_Paige	Improvement	No Change	Worsening	total	improvement_rate	worsening_rate
AI Diagnosis Impact on Agreement
Absent	144	441	11	596	24.2	1.8
Present	30	186	11	227	13.2	4.8

Diagnostic Confidence Analysis

Case Difficulty Analysis

Note for Pathologists: This table shows the impact of AI on agreement stratified by the difficulty of the case (based on initial disagreement).

case_difficulty	Transition_Type	count	percentage
AI Impact by Case Difficulty
Difficult	Improvement	174	21.1
Difficult	No Change	627	76.2
Difficult	Worsening	22	2.7

Note for Pathologists: This plot visualizes the proportion of agreement transitions (Improvement, No Change, Worsening) for each difficulty level.

Disagreement Pattern Analysis

Note for Pathologists: This table shows the most frequent specific combinations of diagnoses (patterns) among the four pathologists and how they changed with AI assistance.

pattern_noAI	pattern_withAI	count	percentage	agreement_change
Top 10 Diagnosis Patterns
Benign-Benign-Benign-Benign	Benign-Benign-Benign-Benign	424	51.5	No Change
Malignant-Malignant-Malignant-Malignant	Malignant-Malignant-Malignant-Malignant	168	20.4	No Change
Suspicious-Benign-Benign-Benign	Benign-Benign-Benign-Benign	59	7.2	Improvement
Benign-Benign-Benign-Suspicious	Benign-Benign-Benign-Benign	26	3.2	Improvement
Suspicious-Benign-Benign-Suspicious	Benign-Benign-Benign-Benign	15	1.8	Improvement
Malignant-Malignant-Suspicious-Malignant	Malignant-Malignant-Malignant-Malignant	9	1.1	Improvement
Benign-Suspicious-Benign-Benign	Benign-Benign-Benign-Benign	8	1.0	Improvement
Benign-Benign-Suspicious-Benign	Benign-Benign-Benign-Benign	7	0.9	Improvement
Suspicious-Benign-Benign-Benign	Suspicious-Benign-Benign-Benign	4	0.5	No Change
Benign-Benign-Benign-Benign	Benign-Benign-Benign-Suspicious	3	0.4	Worsening

Unsupervised Pattern Discovery

Note for Pathologists: This analysis groups cases into ‘clusters’ based on the pattern of agreement changes. Cluster statistics show usually 3 types of behavior (e.g., highly improved, already good, etc.).

cluster	n	percent	improvement_rate	worsening_rate	accuracy_gain
Cluster Summary
1.0	605.0	73.5	0.0	2.1	0.0
2.0	158.0	19.2	78.5	5.7	0.0
3.0	60.0	7.3	83.3	0.0	0.0

Note for Pathologists: This table defines the characteristics of each cluster found above.

cluster	pct_starting_all_agreed	pct_starting_majority	pct_starting_no_agreement	pct_ending_all_agreed	pct_AI_matches_reference	avg_pathologists_changing
Cluster Definitions
1.0	100.0	0.0	0.0	97.9	98.7	0.0
2.0	0.0	100.0	0.0	78.5	88.6	1.3
3.0	0.0	0.0	100.0	60.0	95.0	1.9

Decision Tree Analysis

Note for Pathologists: This decision tree attempts to predict whether AI will improve agreement based on initial pathologist diagnoses and the AI prediction.

Visual Case Timeline Analysis

Note for Pathologists: These timelines visualize the diagnosis of each pathologist and the AI for selected interesting cases.

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Correlation Matrix of Pathologist Behavior

Note for Pathologists: These correlation matrices show the strength of agreement between every pair of pathologists (and AI/Reference Diagnosis). Darker colors indicate stronger agreement.

If we group the diagnoses as “Malignant, Benign, and Suspicious” then without the AI the agreement is 73% (Kappa = 0.69, p<0.001). The agreement increases to 91% with AI (Kappa = 0.88, p<0.001).

Benign, Suspicious, Malignant, agreement among 4 pathologist, noAI


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              824   
   Raters                                  4   
   Agreement %                      73.54369   
   Kappa                           0.6931250   
   z                                61.76535   
   p-value        < .0000001   
 ─────────────────────────────────────────────

Benign, Suspicious, Malignant, agreement among 4 pathologist, withAI


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              827   
   Raters                                  4   
   Agreement %                      91.41475   
   Kappa                           0.8838541   
   z                                69.45499   
   p-value        < .0000001   
 ─────────────────────────────────────────────

7.3 Benign, Others

Transition of Agreement States from Without AI to With AI
Without AI	With AI	Cores	% of Total	% of Row	% of Column	Transition Type
All Agreed	All Agreed	617	74.5	97.6	80.0	No Change
No Agreement	All Agreed	28	3.4	65.1	3.6	Improvement
Majority Agreed	All Agreed	126	15.2	82.4	16.3	Improvement
All Agreed	Majority Agreed	13	1.6	2.1	30.2	Worsening
Majority Agreed	Majority Agreed	20	2.4	13.1	46.5	No Change
No Agreement	Majority Agreed	10	1.2	23.3	23.3	Improvement
Majority Agreed	No Agreement	7	0.8	4.6	50.0	Worsening
All Agreed	No Agreement	2	0.2	0.3	14.3	Worsening
No Agreement	No Agreement	5	0.6	11.6	35.7	No Change

If we further group the diagnoses as “Benign vs Others” then without the AI the agreement is 76% (Kappa = 0.70, p<0.001); and is 93% with AI (Kappa = 0.90, p<0.001).

Benign, Others, agreement among 4 pathologist, noAI


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              824   
   Raters                                  4   
   Agreement %                      76.21359   
   Kappa                           0.7096390   
   z                                49.89726   
   p-value        < .0000001   
 ─────────────────────────────────────────────

Benign, Others, agreement among 4 pathologist, withAI


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              827   
   Raters                                  4   
   Agreement %                      93.10762   
   Kappa                           0.9069606   
   z                                63.88763   
   p-value        < .0000001   
 ─────────────────────────────────────────────

8 Sensitivity, Specificity, PPV, NPV

Pathologist (noAI OR withAI) vs Paige vs Report vs Gold

8.1 Malignant, Benign, Suspicious Consult, Suspicious IHC

Malignant, Benign, Suspicious Consult, Suspicious IHC, agreement among 4 pathologist, noAI vs Report vs AI vs ReferenceDiagnosis


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              824   
   Raters                                  7   
   Agreement %                      0.000000   
   Kappa                           0.1389567   
   z                                31.40548   
   p-value        < .0000001   
 ─────────────────────────────────────────────

Malignant, Benign, Suspicious Consult, Suspicious IHC, agreement among 4 pathologist, withAI vs Report vs AI vs ReferenceDiagnosis

	Interpreter							Total
	P1	P2	P3	P4	Report	AI	ReferenceDiagnosis	Total
Diagnosis
Malignant	201 (24%)	207 (25%)	198 (24%)	205 (25%)	0 (0%)	0 (0%)	0 (0%)	811 (14%)
Benign	580 (70%)	602 (73%)	608 (74%)	601 (73%)	0 (0%)	0 (0%)	0 (0%)	2,391 (41%)
IHC	34 (4.1%)	18 (2.2%)	21 (2.5%)	21 (2.5%)	0 (0%)	0 (0%)	0 (0%)	94 (1.6%)
Consult	12 (1.5%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	12 (0.2%)
Absent	0 (0%)	0 (0%)	0 (0%)	0 (0%)	626 (76%)	599 (72%)	616 (74%)	1,841 (32%)
ASAP	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (0.1%)	1 (<0.1%)
Present	0 (0%)	0 (0%)	0 (0%)	0 (0%)	201 (24%)	228 (28%)	210 (25%)	639 (11%)
Total	827 (100%)	827 (100%)	827 (100%)	827 (100%)	827 (100%)	827 (100%)	827 (100%)	5,789 (100%)


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              827   
   Raters                                  7   
   Agreement %                      0.000000   
   Kappa                           0.1541547   
   z                                33.09248   
   p-value        < .0000001   
 ─────────────────────────────────────────────

8.2 Benign, Suspicious, Malignant

Benign, Suspicious, Malignant, agreement among 4 pathologist, noAI vs Report vs AI vs ReferenceDiagnosis


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              824   
   Raters                                  7   
   Agreement %                      0.000000   
   Kappa                           0.1402228   
   z                                31.60824   
   p-value        < .0000001   
 ─────────────────────────────────────────────

Benign, Suspicious, Malignant, agreement among 4 pathologist, withAI vs Report vs AI vs ReferenceDiagnosis


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              827   
   Raters                                  7   
   Agreement %                      0.000000   
   Kappa                           0.1544038   
   z                                33.13326   
   p-value        < .0000001   
 ─────────────────────────────────────────────

	Interpreter											Total
	P1	P1AI	P2	P2AI	P3	P3AI	P4	P4AI	Report	AI	ReferenceDiagnosis	Total
Diagnosis
Malignant	186 (23%)	200 (24%)	197 (24%)	206 (25%)	179 (22%)	197 (24%)	204 (25%)	204 (25%)	0 (0%)	0 (0%)	0 (0%)	1,573 (17%)
Benign	494 (60%)	577 (70%)	587 (71%)	599 (73%)	600 (73%)	605 (74%)	536 (65%)	598 (73%)	0 (0%)	0 (0%)	0 (0%)	4,596 (51%)
Absent	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	623 (76%)	596 (72%)	613 (74%)	1,832 (20%)
ASAP	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (0.1%)	1 (<0.1%)
Present	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	200 (24%)	227 (28%)	209 (25%)	636 (7.0%)
Suspicious	143 (17%)	46 (5.6%)	39 (4.7%)	18 (2.2%)	44 (5.3%)	21 (2.6%)	83 (10%)	21 (2.6%)	0 (0%)	0 (0%)	0 (0%)	415 (4.6%)
Total	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	9,053 (100%)

1/1
1/1


 MEDICAL DECISION

 Recoded Data for Decision Test Statistics                    
 ──────────────────────────────────────────────────────────── 
                    Gold Positive    Gold Negative    Total   
 ──────────────────────────────────────────────────────────── 
   Test Positive              200              129      329   
   Test Negative                9              485      494   
   Total                      209              614      823   
 ──────────────────────────────────────────────────────────── 


 n                         
 ───────────────────────── 
                           
 ───────────────────────── 
   Total             823   
   Diseased          209   
   Healthy           614   
   Positive Tests    329   
   Negative Tests    494   
   True Test         685   
   Wrong Test        138   
 ───────────────────────── 

                                                 
 ─────────────────────────────────────────────── 
                                                 
 ─────────────────────────────────────────────── 
   Sensitivity                      95.6937799   
   Specificity                      78.9902280   
   Accuracy                         83.2320778   
   Prevalence                       25.3948967   
   Positive Predictive Value        60.7902736   
   Negative Predictive Value        98.1781377   
   Post-test Disease Probability    60.7902736   
   Post-test Health Probability     98.1781377   
   Positive Likelihood Ratio          4.554727   
   Negative Likelihood Ratio        0.05451586   
 ─────────────────────────────────────────────── 


 <div style='margin: 15px; padding: 15px; border-left: 5px solid
 #4CAF50; background: #f1f8e9;'><h3 style='color: #2E7D32; margin-top:
 0;'>Clinical Summary

 <p style='font-size: 16px;'>Analysis: Diagnostic test performance
 evaluation comparing P1 against gold standard ReferenceDiagnosis.

 Sample: 823 cases analyzed with 25.4% disease prevalence.

 Test Performance: The test shows moderate discriminatory ability with
 sensitivity of 95.7% (*Excellent for ruling OUT disease*) and
 specificity of 79.0% (*Limited ability for ruling IN disease*).

 Clinical Utility: This test is most useful for ruling out disease in
 the clinical setting.

 Likelihood Ratios: Positive LR: 4.55 (*Weak evidence for disease*),
 Negative LR: 0.05 (*Strong evidence against disease*)

 Key Findings: When positive, the post-test disease probability is
 60.8% (PPV 60.8%). When negative, the disease probability falls to
 1.8% and the probability of being disease-free is 98.2% (NPV 98.2%).

 <div style='margin: 15px; padding: 10px; border-left: 4px solid
 #2196F3; background: #f8f9fa;'><h4 style='color: #1976D2; margin-top:
 0;'>Clinical Interpretation

 Test Performance Summary:

 Sensitivity: 95.7% - Excellent for ruling out diseaseSpecificity:
 79.0% - Limited ability to rule in diseaseYouden's Index: 0.747 -
 Excellent discriminatory power

 Likelihood Ratio Interpretation:

 Positive LR (4.55): Small but potentially important increase in
 probabilityNegative LR (0.05): Large and often conclusive decrease in
 probability of disease

 Clinical Decision Making:

 Pre-test probability: 25.4%Post-test probability (if positive):
 60.8%Post-test probability (if negative): 98.2%

Note for Pathologists: This table presents the sensitivity, specificity, PPV, and NPV for each pathologist and the AI, compared to the gold standard.

Test	Sens	Spec	PPV	NPV
Decision Tests for Interpreters
P1	NA	NA	NaN	NaN
P1AI	NA	NA	NaN	NaN
P2	NA	NA	NaN	NaN
P2AI	NA	NA	NaN	NaN
P3	NA	NA	NaN	NaN
P3AI	NA	NA	NaN	NaN
P4	NA	NA	NaN	NaN
P4AI	NA	NA	NaN	NaN
AI	NA	NA	NaN	NaN
Report	NA	NA	NaN	NaN

Compare to the literature:

8.3 Benign, Others

Benign, Others, agreement among 4 pathologist, noAI vs Report vs AI vs ReferenceDiagnosis


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              824   
   Raters                                  7   
   Agreement %                      0.000000   
   Kappa                           0.1312138   
   z                                27.86265   
   p-value        < .0000001   
 ─────────────────────────────────────────────

Benign, Others, agreement among 4 pathologist, withAI vs Report vs AI vs ReferenceDiagnosis


 INTERRATER RELIABILITY

 Interrater Reliability                        
 ───────────────────────────────────────────── 
                  Fleiss' Kappa for m Raters   
 ───────────────────────────────────────────── 
   Subjects                              827   
   Raters                                  7   
   Agreement %                      0.000000   
   Kappa                           0.1527087   
   z                                32.02073   
   p-value        < .0000001   
 ─────────────────────────────────────────────

	Interpreter											Total
	P1	P1AI	P2	P2AI	P3	P3AI	P4	P4AI	AI	Report	ReferenceDiagnosis	Total
Diagnosis
Benign	494 (60%)	577 (70%)	587 (71%)	599 (73%)	600 (73%)	605 (74%)	536 (65%)	598 (73%)	0 (0%)	0 (0%)	0 (0%)	4,596 (51%)
Other	329 (40%)	246 (30%)	236 (29%)	224 (27%)	223 (27%)	218 (26%)	287 (35%)	225 (27%)	0 (0%)	0 (0%)	0 (0%)	1,988 (22%)
Absent	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	596 (72%)	623 (76%)	613 (74%)	1,832 (20%)
ASAP	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (0.1%)	1 (<0.1%)
Present	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	227 (28%)	200 (24%)	209 (25%)	636 (7.0%)
Total	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	823 (100%)	9,053 (100%)

Test	Sens	Spec	PPV	NPV
Decision Tests for Interpreters
P1	NA	NA	NaN	NaN
P1AI	NA	NA	NaN	NaN
P2	NA	NA	NaN	NaN
P2AI	NA	NA	NaN	NaN
P3	NA	NA	NaN	NaN
P3AI	NA	NA	NaN	NaN
P4	NA	NA	NaN	NaN
P4AI	NA	NA	NaN	NaN
AI	NA	NA	NaN	NaN
Report	NA	NA	NaN	NaN